Gene Amplification of ErbB-2: From Gene to Therapy
نویسندگان
چکیده
6 Mechanisms of Resistance................................................... 9 6.1 Functional Redundancy Among ErbB Family Members...... 10 6.2 Role for Loss of Negative Regulators................................... 11 6.3 Accumulation of Soluble p95-ErbB-2................................... 11 6.4 Role for MUC4: Altered Receptor–Antibody Interaction .... 11 6.5 Crosstalk Between ErbB-2 and Notch Signaling Pathways................................................................ 12
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Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification.
The recombinant oncotoxin OLX-209 [e23(Fv)PE38KDEL] has been developed to target cancers with erbB-2 expression and is nearing a clinical trial. Important in clinical planning is the selection of patients on the basis of tumor expression of erbB-2. ErbB-2 gene amplification occurs in cancers of the breast, stomach, and ovary. Patients with these diseases and evident overexpression are candidate...
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